Tripropyl orthoformate Property

Boiling point:

106-108 °C/40 mmHg (lit.)

Density 

0.883 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.407(lit.)

Flash point:

162 °F

form 

Liquid

Specific Gravity

0.883

color 

Clear colorless

Sensitive 

Moisture Sensitive

BRN 

1744249

CAS DataBase Reference

621-76-1(CAS DataBase Reference)

NIST Chemistry Reference

Tripropyl orthoformate(621-76-1)

EPA Substance Registry System

Tripropyl orthoformate (621-76-1)

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39-37/39

RIDADR 

1993

WGK Germany 

1

F 

10-21

TSCA 

Yes

HS Code 

29159000

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Tripropyl orthoformate Chemical Properties,Usage,Production

Chemical Properties

clear colorless liquid

Uses

Tripropoxymethane can be used in the lipase-?catalyzed esterification aimed at the kinetic resolution of racemic acids, circumventing the adverse effects of the water formed in the course of the reaction.

Uses

Tripropyl orthoformate was used as alcohol donor to investigate the activity and enantioselectivity of Novozym 435 in the esterification of rac-fenoprofen in methylcyclohexane. It may be used as a drying agent during the synthesis of squaraine derivatives.

Synthesis Reference(s)

Journal of the American Chemical Society, 77, p. 3801, 1955 DOI: 10.1021/ja01619a036

General Description

Gas phase reactions of the rare earth metal cations with tripropyl orthoformate were studied by Fourier transform ion cyclotron resonance mass spectrometry.